Ultrahigh resolution mouse optical coherence tomography to aid intraocular injection in retinal gene therapy research
MC Butler, JM Sullivan - JoVE (Journal of Visualized Experiments), 2018 - jove.com
HR-SD-OCT is utilized to monitor the progression of photoreceptor degeneration in live
mouse models, assess the delivery of therapeutic agents into the subretinal space, and to
evaluate toxicity and efficacy in vivo. HR-SD-OCT uses near infrared light (800-880 nm) and
has optics specifically designed for the unique optics of the mouse eye with sub-2-micron
axial resolution. Transgenic mouse models of outer retinal (photoreceptor) degeneration
and controls were imaged to assess the disease progression. Pulled glass microneedles …
mouse models, assess the delivery of therapeutic agents into the subretinal space, and to
evaluate toxicity and efficacy in vivo. HR-SD-OCT uses near infrared light (800-880 nm) and
has optics specifically designed for the unique optics of the mouse eye with sub-2-micron
axial resolution. Transgenic mouse models of outer retinal (photoreceptor) degeneration
and controls were imaged to assess the disease progression. Pulled glass microneedles …