[HTML][HTML] Non-canonical interactions between heat shock cognate protein 70 (Hsc70) and Bcl2-associated anthanogene (BAG) co-chaperones are important for client …
JN Rauch, ERP Zuiderweg, JE Gestwicki - Journal of Biological Chemistry, 2016 - ASBMB
Heat shock cognate protein 70 (Hsc70) regulates protein homeostasis through its reversible
interactions with client proteins. Hsc70 has two major domains: a nucleotide-binding domain
(NBD), that hydrolyzes ATP, and a substrate-binding domain (SBD), where clients are
bound. Members of the BAG family of co-chaperones, including Bag1 and Bag3, are known
to accelerate release of both ADP and client from Hsc70. The release of nucleotide is known
to be mediated by interactions between the conserved BAG domain and the Hsc70 NBD …
interactions with client proteins. Hsc70 has two major domains: a nucleotide-binding domain
(NBD), that hydrolyzes ATP, and a substrate-binding domain (SBD), where clients are
bound. Members of the BAG family of co-chaperones, including Bag1 and Bag3, are known
to accelerate release of both ADP and client from Hsc70. The release of nucleotide is known
to be mediated by interactions between the conserved BAG domain and the Hsc70 NBD …