Infection courses, virological features and IFN-α responses of HBV genotypes in cell culture and animal models
M Zhang, Z Zhang, M Imamura, M Osawa… - Journal of …, 2021 - Elsevier
Background & Aims HBV consists of 9 major genotypes (A to I), 1 minor strain (designated J)
and multiple subtypes, which may be associated with different clinical characteristics. As
only cell lines expressing genotype D3 have been established, herein, we aimed to
establish stable cell lines producing high-titer cell culture-generated HBV (HBVcc) of
different genotypes and to explore their infectivity, virological features and responses to
treatment. Methods Stable cell lines producing high titers of HBV genotype A2, B2, C1, E …
and multiple subtypes, which may be associated with different clinical characteristics. As
only cell lines expressing genotype D3 have been established, herein, we aimed to
establish stable cell lines producing high-titer cell culture-generated HBV (HBVcc) of
different genotypes and to explore their infectivity, virological features and responses to
treatment. Methods Stable cell lines producing high titers of HBV genotype A2, B2, C1, E …