Pathological ventricular remodeling: mechanisms: part 1 of 2
Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society,
and the economy. As a result, the need for new therapeutic advances and novel medical
devices is urgent. Disease-related left ventricular remodeling is a complex process involving
cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and
electrophysiological remodeling. Because these events are highly interrelated, targeting a …
rehospitalization rates remain distressingly high, substantially affecting individuals, society,
and the economy. As a result, the need for new therapeutic advances and novel medical
devices is urgent. Disease-related left ventricular remodeling is a complex process involving
cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and
electrophysiological remodeling. Because these events are highly interrelated, targeting a …
Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.
Am Heart Assoc