Rheumatoid arthritis is a chronic inflammatory disorder whose origin of defect has been the
subject of extensive research during the past few decades. While a number of immune and
non-immune cell types participate in the development of chronic destructive inflammation in
the arthritic joint, synovial fibroblasts have emerged as key effector cells capable of
modulating both joint destruction and propagation of inflammation. Ample evidence of
aberrant changes in the morphology and biochemical behaviour of rheumatoid arthritis …