Modulation of lipopolysaccharide-induced tumor necrosis factor-α and nitric oxide production by dopamine receptor agonists and antagonists in mice
The effects of various agonists and antagonists of dopamine D1 and D2 receptors on
lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) and nitrix oxide (NO)
production was investigated in mice. Pretreatment of animals with bromocryptine or
quinpirole, agonists of dopamine D2 receptors caused a blunting of both the TNF-α and NO
responses to LPS injected intraperitoneally. Sulpiride, an antagonist of dopamine D2
receptors, decreased the LPS-induced TNF-α plasma levels in a dose-dependent manner …
lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) and nitrix oxide (NO)
production was investigated in mice. Pretreatment of animals with bromocryptine or
quinpirole, agonists of dopamine D2 receptors caused a blunting of both the TNF-α and NO
responses to LPS injected intraperitoneally. Sulpiride, an antagonist of dopamine D2
receptors, decreased the LPS-induced TNF-α plasma levels in a dose-dependent manner …
