ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading
A Fernandez, N Matias, R Fucho, V Ribas… - Journal of …, 2013 - Elsevier
Background & Aims The pathogenesis of alcohol-induced liver disease (ALD) is poorly
understood. Here, we examined the role of acid sphingomyelinase (ASMase) in alcohol
induced hepatic endoplasmic reticulum (ER) stress, a key mechanism of ALD. Methods We
examined ER stress, lipogenesis, hyperhomocysteinemia, mitochondrial cholesterol
(mChol) trafficking and susceptibility to LPS and concanavalin-A in ASMase−/− mice fed
alcohol. Results Alcohol feeding increased SREBP-1c, DGAT-2, and FAS mRNA in …
understood. Here, we examined the role of acid sphingomyelinase (ASMase) in alcohol
induced hepatic endoplasmic reticulum (ER) stress, a key mechanism of ALD. Methods We
examined ER stress, lipogenesis, hyperhomocysteinemia, mitochondrial cholesterol
(mChol) trafficking and susceptibility to LPS and concanavalin-A in ASMase−/− mice fed
alcohol. Results Alcohol feeding increased SREBP-1c, DGAT-2, and FAS mRNA in …