[HTML][HTML] Vascularized composite allograft tolerance across MHC barriers in a large animal model
DA Leonard, JM Kurtz, C Mallard, A Albritton… - American Journal of …, 2014 - Elsevier
Vascularized composite allograft (VCA) transplantation can restore form and function
following severe craniofacial injuries, extremity amputations or massive tissue loss. The
induction of transplant tolerance would eliminate the need for long-term
immunosuppression, realigning the risk–benefit ratio for these life-enhancing procedures.
Skin, a critical component of VCA, has consistently presented the most stringent challenge to
transplant tolerance. Here, we demonstrate, in a clinically relevant miniature swine model …
following severe craniofacial injuries, extremity amputations or massive tissue loss. The
induction of transplant tolerance would eliminate the need for long-term
immunosuppression, realigning the risk–benefit ratio for these life-enhancing procedures.
Skin, a critical component of VCA, has consistently presented the most stringent challenge to
transplant tolerance. Here, we demonstrate, in a clinically relevant miniature swine model …