[HTML][HTML] Functions of the plasminogen receptor Plg‐RKT
LA Miles, JP Vago, LP Sousa, RJ Parmer - Journal of Thrombosis and …, 2020 - Elsevier
Plg‐R KT is a structurally unique transmembrane plasminogen receptor with both N‐and C‐
terminal domains exposed on the extracellular face of the cell. Its C‐terminal lysine functions
to tether plasminogen to cell surfaces. Overexpression of Plg‐R KT increases cell surface
plasminogen binding capacity while genetic deletion of Plg‐R KT decreases plasminogen
binding. Plasminogen binding to Plg‐R KT results in promotion of plasminogen activation to
the broad spectrum serine protease plasmin. This function is promoted by the physical …
terminal domains exposed on the extracellular face of the cell. Its C‐terminal lysine functions
to tether plasminogen to cell surfaces. Overexpression of Plg‐R KT increases cell surface
plasminogen binding capacity while genetic deletion of Plg‐R KT decreases plasminogen
binding. Plasminogen binding to Plg‐R KT results in promotion of plasminogen activation to
the broad spectrum serine protease plasmin. This function is promoted by the physical …
