The biochemistry, physiology and pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo
B Van De Craen, PJ Declerck, A Gils - Thrombosis research, 2012 - Elsevier
Plasminogen activator inhibitor-1 (PAI-1) is the primary physiological inhibitor of both tissue-
type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA) and is
consequently one the most important inhibitors of the plasminogen/plasmin system. PAI-1
attenuates fibrinolysis and increased levels of active PAI-1 have been associated with an
increased risk for cardiovascular diseases. PAI-1 knock-out mice as well as PAI-1
overexpressing mice have been generated and characterized to study the role of PAI-1 in …
type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA) and is
consequently one the most important inhibitors of the plasminogen/plasmin system. PAI-1
attenuates fibrinolysis and increased levels of active PAI-1 have been associated with an
increased risk for cardiovascular diseases. PAI-1 knock-out mice as well as PAI-1
overexpressing mice have been generated and characterized to study the role of PAI-1 in …