MIF signaling blocking alleviates airway inflammation and airway epithelial barrier disruption in a HDM-induced asthma model
H Lan, L Luo, Y Chen, M Wang, Z Yu, Y Gong - Cellular Immunology, 2020 - Elsevier
Recent studies have indicated that Macrophage migration inhibitory factor (MIF) plays an
important role in the prevention and treatment of asthma. However the role of MIF in airway
inflammation and airway epithelial barrier disruption in house dust mite (HDM)-induced
asthma has not been addressed. We hypothesized that MIF contributed to HDM-induced the
production of Th2-associated cytokines and E-cadherin dysfunction in asthmatic mice and
16HBE cells. In vivo, a HDM-induced asthma mouse model was set up and mice treated with …
important role in the prevention and treatment of asthma. However the role of MIF in airway
inflammation and airway epithelial barrier disruption in house dust mite (HDM)-induced
asthma has not been addressed. We hypothesized that MIF contributed to HDM-induced the
production of Th2-associated cytokines and E-cadherin dysfunction in asthmatic mice and
16HBE cells. In vivo, a HDM-induced asthma mouse model was set up and mice treated with …