[HTML][HTML] Autoantibody profiling in multiple sclerosis using arrays of human protein fragments

B Ayoglu, A Häggmark, M Khademi, T Olsson… - Molecular & Cellular …, 2013 - ASBMB
Profiling the autoantibody repertoire with large antigen collections is emerging as a powerful
tool for the identification of biomarkers for autoimmune diseases. Here, a systematic and
undirected approach was taken to screen for profiles of IgG in human plasma from 90
individuals with multiple sclerosis related diagnoses. Reactivity pattern of 11,520 protein
fragments (representing∼ 38% of all human protein encoding genes) were generated on
planar protein microarrays built within the Human Protein Atlas. For more than 2,000 …