[HTML][HTML] Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway
K Nomura, H Imai, T Koumura, M Arai… - Journal of Biological …, 1999 - ASBMB
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a key enzyme in the
protection of biomembranes exposed to oxidative stress. We investigated the role of
mitochondrial PHGPx in apoptosis using RBL2H3 cells that overexpressed mitochondrial
PHGPx (M15 cells), cells that overexpressed non-mitochondrial PHGPx (L9 cells), and
control cells (S1 cells). The morphological changes and fragmentation of DNA associated
with apoptosis occurred within 15 h in S1 and L9 cells upon exposure of cells to 2 …
protection of biomembranes exposed to oxidative stress. We investigated the role of
mitochondrial PHGPx in apoptosis using RBL2H3 cells that overexpressed mitochondrial
PHGPx (M15 cells), cells that overexpressed non-mitochondrial PHGPx (L9 cells), and
control cells (S1 cells). The morphological changes and fragmentation of DNA associated
with apoptosis occurred within 15 h in S1 and L9 cells upon exposure of cells to 2 …