Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants
AA Sneddon, HC Wu, A Farquharson, I Grant, JR Arthur… - Atherosclerosis, 2003 - Elsevier
Phospholipid hydroperoxide glutathione peroxidase (GPx4) is the only antioxidant enzyme
known to directly reduce phospholipid hydroperoxides within membranes and lipoproteins,
acting in conjunction with α-tocopherol to inhibit lipid peroxidation. Peroxidation of lipids has
been implicated in a number of pathophysiological processes, including inflammation and
atherogenesis. We investigated the relative positive and negative effects of specific
polyunsaturated fatty acids (PUFAs) and inflammatory cytokines on the activity and gene …
known to directly reduce phospholipid hydroperoxides within membranes and lipoproteins,
acting in conjunction with α-tocopherol to inhibit lipid peroxidation. Peroxidation of lipids has
been implicated in a number of pathophysiological processes, including inflammation and
atherogenesis. We investigated the relative positive and negative effects of specific
polyunsaturated fatty acids (PUFAs) and inflammatory cytokines on the activity and gene …