Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction
DM Bers - Annual review of physiology, 2014 - annualreviews.org
Synchronized SR calcium (Ca) release is critical to normal cardiac myocyte excitation-
contraction coupling, and ideally this release shuts off completely between heartbeats.
However, other SR Ca release events are referred to collectively as SR Ca leak (which
includes Ca sparks and waves as well as smaller events not detectable as Ca sparks).
Much, but not all, of the SR Ca leak occurs via ryanodine receptors and can be exacerbated
in pathological states such as heart failure. The extent of SR Ca leak is important because it …
contraction coupling, and ideally this release shuts off completely between heartbeats.
However, other SR Ca release events are referred to collectively as SR Ca leak (which
includes Ca sparks and waves as well as smaller events not detectable as Ca sparks).
Much, but not all, of the SR Ca leak occurs via ryanodine receptors and can be exacerbated
in pathological states such as heart failure. The extent of SR Ca leak is important because it …