Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-β1-induced release of extracellular fibroblast growth factor-2 and …
N Khalil, YD Xu, R O'Connor, V Duronio - Journal of Biological Chemistry, 2005 - jbc.org
Idiopathic pulmonary fibrosis (IPF; a progressive lung disease) is characterized by
parenchymal remodeling with enlarged air spaces called honeycomb cysts and palisades of
fibroblasts called fibroblast foci. In IPF, lung epithelial cells covering honeycomb cysts and
fibroblast foci aberrantly express the active conformation of the potent fibrogenic cytokine
transforming growth factor-β1 (TGF-β1). Using explanted rat lung slices, we transfected
alveolar epithelial cells with the retrovirus pMX containing a site-directed mutation in which …
parenchymal remodeling with enlarged air spaces called honeycomb cysts and palisades of
fibroblasts called fibroblast foci. In IPF, lung epithelial cells covering honeycomb cysts and
fibroblast foci aberrantly express the active conformation of the potent fibrogenic cytokine
transforming growth factor-β1 (TGF-β1). Using explanted rat lung slices, we transfected
alveolar epithelial cells with the retrovirus pMX containing a site-directed mutation in which …