Rho kinases in health and disease: from basic science to translational research
G Loirand - Pharmacological reviews, 2015 - Elsevier
Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important
physiologic functions, S including cell contraction, migration, proliferation, adhesion, and
inflammation. Several excellent review articles dealing with ROCK function and regulation
have been published over the past few years. Although a brief overview of general
molecular, biochemical, and functional properties of ROCKs is included, an effort has been …
dynamics downstream of Rho GTPases that participate in the control of important
physiologic functions, S including cell contraction, migration, proliferation, adhesion, and
inflammation. Several excellent review articles dealing with ROCK function and regulation
have been published over the past few years. Although a brief overview of general
molecular, biochemical, and functional properties of ROCKs is included, an effort has been …
