Regulation of lymphoid homeostasis by interleukin-15
JP Lodolce, PR Burkett, RM Koka, DL Boone… - Cytokine & growth factor …, 2002 - Elsevier
Interleukin (IL)-15 is a member of the common gamma chain family of cytokines, and is
closely related to IL-2. While these two cytokines share several important biological
functions in vitro, recent mouse models have demonstrated unique roles for these two
cytokines in supporting lymphoid homeostasis in vivo. IL-15 has been shown to regulate the
homeostasis of both innate and adaptive immune cells, and this review will discuss several
ways in which this pleiotropic cytokine may support lymphoid homeostasis.
closely related to IL-2. While these two cytokines share several important biological
functions in vitro, recent mouse models have demonstrated unique roles for these two
cytokines in supporting lymphoid homeostasis in vivo. IL-15 has been shown to regulate the
homeostasis of both innate and adaptive immune cells, and this review will discuss several
ways in which this pleiotropic cytokine may support lymphoid homeostasis.
