Aquaporin-4 (AQP4) is a water transport protein expressed in glial cell plasma membranes,
including glial cell foot processes lining the blood-brain barrier. AQP4 deletion in mice
reduces cytotoxic brain edema produced by different pathologies. To determine whether
AQP4 is rate-limiting for brain water accumulation and whether altered AQP4 expression, as
occurs in various pathologies, could have functional importance, we generated mice that
overexpressed AQP4 in brain glial cells by a transgenic approach using the glial fibrillary …