APOE4 homozygosity has been associated with an increased risk of sporadic Alzheimer's
disease through a mechanism, which has yet to be defined. Recent evidence has suggested
that microvascular basement membrane injury may be a critical factor in the pathogenesis of
AD-related dementia. In previous studies, we have shown that the synaptic organizing
protein agrin can be found in neurons, and is a major component of the brain microvascular
basement membrane. Here, we compare the basement membrane surface area of cortical …