[HTML][HTML] Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies: Thematic Review Series: ApoE and Lipid …
M Shinohara, M Tachibana, T Kanekiyo, G Bu - Journal of lipid research, 2017 - ASBMB
Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP) 1
in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the
most studied by genetic, neuropathological, and biomarker analyses (clinical studies) or
cellular and animal model systems (preclinical studies) over the last 25 years. Although
there are some conflicting reports, accumulating evidence from preclinical studies indicates
that LRP1 not only regulates the metabolism of amyloid-β peptides (Aβs) in the brain and …
in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the
most studied by genetic, neuropathological, and biomarker analyses (clinical studies) or
cellular and animal model systems (preclinical studies) over the last 25 years. Although
there are some conflicting reports, accumulating evidence from preclinical studies indicates
that LRP1 not only regulates the metabolism of amyloid-β peptides (Aβs) in the brain and …
