APOE ε4 genotype and longitudinal changes in cerebral blood flow in normal aging
M Thambisetty, L Beason-Held, Y An… - Archives of …, 2010 - jamanetwork.com
Objective To study differences in longitudinal changes in regional cerebral blood flow (rCBF)
between apolipoprotein E (APOE) ε4 carriers and noncarriers in nondemented older adults
from the Baltimore Longitudinal Study of Aging using positron emission tomography in order
to determine whether there are regionally specific longitudinal changes in rCBF inAPOEε4
carriers that might be related to its well-established role as a genetic risk factor for Alzheimer
disease. Design, Setting, and Participants Using oxygen 15 ([15 O])–labeled water positron …
between apolipoprotein E (APOE) ε4 carriers and noncarriers in nondemented older adults
from the Baltimore Longitudinal Study of Aging using positron emission tomography in order
to determine whether there are regionally specific longitudinal changes in rCBF inAPOEε4
carriers that might be related to its well-established role as a genetic risk factor for Alzheimer
disease. Design, Setting, and Participants Using oxygen 15 ([15 O])–labeled water positron …