Studies to determine the basis for hyperkalemia in recipients of a renal transplant who are treated with cyclosporine.
KS Kamel, JH Ethier, S Quaggin, A Levin… - Journal of the …, 1992 - journals.lww.com
Hyperkalemia is commonly encountered in patients who receive a renal transplant and the
immunosuppressive drug, cyclosporine. There is also a high incidence of hypertension
(which is thought to be due to expansion of the extracellular fluid volume) and
hyperchloremic metabolic acidosis in this group of patients. This constellation of findings led
to the suspicion of the possibility that their basis might be type II hypoaldosteronism. To test
this hypothesis, 12 patients with hyperkalemia (plasma K+, 5.1+/-0.2 mmol/L at the time of …
immunosuppressive drug, cyclosporine. There is also a high incidence of hypertension
(which is thought to be due to expansion of the extracellular fluid volume) and
hyperchloremic metabolic acidosis in this group of patients. This constellation of findings led
to the suspicion of the possibility that their basis might be type II hypoaldosteronism. To test
this hypothesis, 12 patients with hyperkalemia (plasma K+, 5.1+/-0.2 mmol/L at the time of …