Calcineurin and sorting-related receptor with A-type repeats interact to regulate the renal Na+-K+-2Cl− cotransporter
A Borschewski, N Himmerkus, C Boldt… - Journal of the …, 2016 - journals.lww.com
The furosemide-sensitive Na+-K+-2Cl−-cotransporter (NKCC2) is crucial for NaCl
reabsorption in kidney thick ascending limb (TAL) and drives the urine concentrating
mechanism. NKCC2 activity is modulated by N-terminal phosphorylation and
dephosphorylation. Serine-threonine kinases that activate NKCC2 have been identified, but
less is known about phosphatases that deactivate NKCC2. Inhibition of calcineurin
phosphatase has been shown to stimulate transport in the TAL and the distal convoluted …
reabsorption in kidney thick ascending limb (TAL) and drives the urine concentrating
mechanism. NKCC2 activity is modulated by N-terminal phosphorylation and
dephosphorylation. Serine-threonine kinases that activate NKCC2 have been identified, but
less is known about phosphatases that deactivate NKCC2. Inhibition of calcineurin
phosphatase has been shown to stimulate transport in the TAL and the distal convoluted …