[HTML][HTML] Src family protein tyrosine kinase regulates the basolateral K channel in the distal convoluted tubule (DCT) by phosphorylation of KCNJ10 protein
C Zhang, L Wang, S Thomas, K Wang, DH Lin… - Journal of Biological …, 2013 - ASBMB
The loss of function of the basolateral K channels in the distal nephron causes electrolyte
imbalance. The aim of this study is to examine the role of Src family protein tyrosine kinase
(SFK) in regulating K channels in the basolateral membrane of the mouse initial distal
convoluted tubule (DCT1). Single-channel recordings confirmed that the 40-picosiemen (pS)
K channel was the only type of K channel in the basolateral membrane of DCT1. The
suppression of SFK reversibly inhibited the basolateral 40-pS K channel activity in cell …
imbalance. The aim of this study is to examine the role of Src family protein tyrosine kinase
(SFK) in regulating K channels in the basolateral membrane of the mouse initial distal
convoluted tubule (DCT1). Single-channel recordings confirmed that the 40-picosiemen (pS)
K channel was the only type of K channel in the basolateral membrane of DCT1. The
suppression of SFK reversibly inhibited the basolateral 40-pS K channel activity in cell …
