Kir4. 1/Kir5. 1 Activity Is Essential for Dietary Sodium Intake–Induced Modulation of Na-Cl Cotransporter
P Wu, ZX Gao, XT Su, MX Wang… - Journal of the …, 2019 - journals.lww.com
Background Dietary sodium intake regulates the thiazide-sensitive Na-Cl cotransporter
(NCC) in the distal convoluted tubule (DCT). Whether the basolateral, inwardly rectifying
potassium channel Kir4. 1/Kir5. 1 (a heterotetramer of Kir4. 1/Kir5. 1) in the DCT is essential
for mediating the effect of dietary sodium intake on NCC activity is unknown. Methods We
used electrophysiology, renal clearance techniques, and immunoblotting to examine effects
of Kir4. 1/Kir5. 1 in the DCT and NCC in wild-type and kidney-specific Kir4. 1 knockout mice …
(NCC) in the distal convoluted tubule (DCT). Whether the basolateral, inwardly rectifying
potassium channel Kir4. 1/Kir5. 1 (a heterotetramer of Kir4. 1/Kir5. 1) in the DCT is essential
for mediating the effect of dietary sodium intake on NCC activity is unknown. Methods We
used electrophysiology, renal clearance techniques, and immunoblotting to examine effects
of Kir4. 1/Kir5. 1 in the DCT and NCC in wild-type and kidney-specific Kir4. 1 knockout mice …