[HTML][HTML] Key role for scavenger receptor BI in the integrative physiology of host defense during bacterial pneumonia
KM Gowdy, JH Madenspacher, KM Azzam… - Mucosal …, 2015 - Elsevier
Abstract Scavenger receptor BI (SR-BI) is a multirecognition receptor that regulates
cholesterol trafficking and cardiovascular inflammation. Although it is expressed by
neutrophils (PMNs) and lung-resident cells, no role for SR-BI has been defined in pulmonary
immunity. Herein, we report that, compared with SR-BI+/+ counterparts, SR-BI−/− mice suffer
markedly increased mortality during bacterial pneumonia associated with higher bacterial
burden in the lung and blood, deficient induction of the stress glucocorticoid corticosterone …
cholesterol trafficking and cardiovascular inflammation. Although it is expressed by
neutrophils (PMNs) and lung-resident cells, no role for SR-BI has been defined in pulmonary
immunity. Herein, we report that, compared with SR-BI+/+ counterparts, SR-BI−/− mice suffer
markedly increased mortality during bacterial pneumonia associated with higher bacterial
burden in the lung and blood, deficient induction of the stress glucocorticoid corticosterone …
