Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol [S]
J Li, X Zheng, N Lou, W Zhong, D Yan - Journal of lipid research, 2016 - jlr.org
Oxysterols are 27-carbon oxidized derivatives of cholesterol or by-products of cholesterol
biosynthesis that can induce cell apoptosis in addition to a number of other bioactions.
However, the mechanisms underlying this cytotoxicity are not completely understood. ORP8
is a member of the oxysterol binding protein-related protein (ORP) family, implicated in
cellular lipid homeostasis, migration, and organization of the microtubule cytoskeleton. Here,
we report that 25-hydroxycholesterol (OHC) induced apoptosis of the hepatoma cell lines …
biosynthesis that can induce cell apoptosis in addition to a number of other bioactions.
However, the mechanisms underlying this cytotoxicity are not completely understood. ORP8
is a member of the oxysterol binding protein-related protein (ORP) family, implicated in
cellular lipid homeostasis, migration, and organization of the microtubule cytoskeleton. Here,
we report that 25-hydroxycholesterol (OHC) induced apoptosis of the hepatoma cell lines …
