LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms
F Morello, E Saglio, A Noghero, D Schiavone… - Atherosclerosis, 2009 - Elsevier
AIMS: Liver X receptors α and β (LXRα, LXRβ) are key regulators of cholesterol
homeostasis. The effects of LXR ligands on endothelial cells are largely unknown. While
oxysterol LXR agonists can increase the endothelial–leukocyte interaction, synthetic LXR
agonists are anti-atherogenic and anti-inflammatory. Mechanistic differences may underlie
such findings. METHODS AND RESULTS: LXRα and LXRβ were found to be expressed in
human endothelial cells. While synthetic LXR agonists could blunt the LPS-induced up …
homeostasis. The effects of LXR ligands on endothelial cells are largely unknown. While
oxysterol LXR agonists can increase the endothelial–leukocyte interaction, synthetic LXR
agonists are anti-atherogenic and anti-inflammatory. Mechanistic differences may underlie
such findings. METHODS AND RESULTS: LXRα and LXRβ were found to be expressed in
human endothelial cells. While synthetic LXR agonists could blunt the LPS-induced up …