Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK–eIF2α–ATF4 axis
Y Watanabe, T Sasaki, S Miyoshi, M Shimizu… - Journal of Biological …, 2021 - jbc.org
Insulin-induced genes (INSIGs) encode endoplasmic reticulum–resident proteins that
regulate intracellular cholesterol metabolism. Oxysterols are oxygenated derivatives of
cholesterol, some of which orchestrate lipid metabolism via interaction with INSIGs.
Recently, it was reported that expression of activating transcription factor-4 (ATF4) was
induced by certain oxysterols; the precise of mechanism is unclear. Herein, we show that
INSIGs mediate ATF4 upregulation upon interaction with oxysterol. Oxysterols that possess …
regulate intracellular cholesterol metabolism. Oxysterols are oxygenated derivatives of
cholesterol, some of which orchestrate lipid metabolism via interaction with INSIGs.
Recently, it was reported that expression of activating transcription factor-4 (ATF4) was
induced by certain oxysterols; the precise of mechanism is unclear. Herein, we show that
INSIGs mediate ATF4 upregulation upon interaction with oxysterol. Oxysterols that possess …