[PDF][PDF] Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation,
division, survival, and cancer development. In this review, the EGFR structure and its
mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR
interaction, and the progress in the development of EGFR inhibitors have been explored.
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation,
division, survival, and cancer development. In this review, the EGFR structure and its
mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR
interaction, and the progress in the development of EGFR inhibitors have been explored.
Abstract
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.
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