In recent decades, cancer treatment has been revolutionized by molecular discoveries that
have provided new and more specific targets for therapy. 1 Human epidermal growth factor
receptor 2 (HER2) was first discovered in the late 1970s and subsequently found to be
overexpressed in approximately 25% of breast cancers. 2 More recent investigations
identified HER2 overexpression in gastric cancers and other malignancies of primarily
epithelial origin. 3 The discovery of HER2 and its role in a particularly aggressive subtype of …