[HTML][HTML] Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells
JH Lorch, J Klessner, JK Park, S Getsios, YL Wu… - Journal of Biological …, 2004 - ASBMB
The epidermal growth factor receptor (EGFR) has been proposed as a key modulator of
cadherin-containing intercellular junctions, particularly in tumors that overexpress this
tyrosine kinase. Here the EGFR tyrosine kinase inhibitor PKI166 and EGFR blocking
antibody C225, both of which are used clinically to treat head and neck cancers, were used
to determine the effects of EGFR inhibition on intercellular junction assembly and adhesion
in oral squamous cell carcinoma cells. EGFR inhibition resulted in a transition from a …
cadherin-containing intercellular junctions, particularly in tumors that overexpress this
tyrosine kinase. Here the EGFR tyrosine kinase inhibitor PKI166 and EGFR blocking
antibody C225, both of which are used clinically to treat head and neck cancers, were used
to determine the effects of EGFR inhibition on intercellular junction assembly and adhesion
in oral squamous cell carcinoma cells. EGFR inhibition resulted in a transition from a …