Eukaryotic cells maintain a sophisticated network of intracellular membranous system to
ensure the proper distribution and compartmentalization of cellular proteins critical for
diverse functions such as cell division or cell-cell communication. Yet, little is known about
the mechanism that regulates the homeostasis of this system. While analyzing the impact of
sorting nexins on the trafficking of membrane type matrix metalloproteinases, we
unexpectedly discovered that the expression of SNX10 induced the formation of giant …