The DREAM complex: master coordinator of cell cycle-dependent gene expression
S Sadasivam, JA DeCaprio - Nature Reviews Cancer, 2013 - nature.com
Nature Reviews Cancer, 2013•nature.com
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F,
BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0
phase and coordinates periodic gene expression with peaks during the G1/S and G2/M
phases. Perturbations in DREAM complex regulation shift the balance from quiescence
towards proliferation and contribute to the increased mitotic gene expression levels that are …
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F,
BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0
phase and coordinates periodic gene expression with peaks during the G1/S and G2/M
phases. Perturbations in DREAM complex regulation shift the balance from quiescence
towards proliferation and contribute to the increased mitotic gene expression levels that are …
Abstract
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis.
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