SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy
Y You, WZ Li, S Zhang, B Hu, YX Li, HD Li, HH Tang… - Journal of …, 2018 - Elsevier
Background & Aims Alcoholic liver disease (ALD) is a major cause of morbidity and mortality
worldwide. However, the cellular defense mechanisms underlying ALD are not well
understood. Recent studies highlighted the involvement of chaperone-mediated autophagy
(CMA) in regulating hepatic lipid metabolism. Sorting nexin (SNX)-10 has a regulatory
function in endolysosomal trafficking and stabilisation. Here, we investigated the roles of
SNX10 in CMA activation and in the pathogenesis of alcohol-induced liver injury and …
worldwide. However, the cellular defense mechanisms underlying ALD are not well
understood. Recent studies highlighted the involvement of chaperone-mediated autophagy
(CMA) in regulating hepatic lipid metabolism. Sorting nexin (SNX)-10 has a regulatory
function in endolysosomal trafficking and stabilisation. Here, we investigated the roles of
SNX10 in CMA activation and in the pathogenesis of alcohol-induced liver injury and …