Although accumulated evidence supports the concept of endosomal signaling of receptor
tyrosine kinases, most results are generated from studies of epidermal growth factor receptor
(EGFR). It is not clear whether the concept of endosomal signaling could be generally
applied to the other receptor tyrosine kinases. For example, platelet-derived growth factor
receptor (PDGFR) is very similar to EGFR in terms of both signaling and trafficking; however,
little is known about the endosomal signaling of PDGFR. In this research, we applied the …