A cytomegalovirus-based vaccine expressing a single tumor-specific CD8+ T-cell epitope delays tumor growth in a murine model of prostate cancer
EN Klyushnenkova, DV Kouiavskaia… - Journal of …, 2012 - journals.lww.com
Cytomegalovirus (CMV) is a highly immunogenic virus that results in a persistent, life-long
infection in the host typically with no ill effects. Certain unique features of CMV, including its
capacity to actively replicate in the presence of strong host CMV-specific immunity, may give
CMV an advantage compared with other virus-based vaccine delivery platforms. In the
present study, we tested the utility of mouse CMV (mCMV)-based vaccines expressing
human prostate-specific antigen (PSA) for prostate cancer immunotherapy in double …
infection in the host typically with no ill effects. Certain unique features of CMV, including its
capacity to actively replicate in the presence of strong host CMV-specific immunity, may give
CMV an advantage compared with other virus-based vaccine delivery platforms. In the
present study, we tested the utility of mouse CMV (mCMV)-based vaccines expressing
human prostate-specific antigen (PSA) for prostate cancer immunotherapy in double …