[HTML][HTML] Efficient reabsorption of transintestinally excreted cholesterol is a strong determinant for cholesterol disposal in mice [S]
IP van de Peppel, A Bertolini, TH van Dijk… - Journal of Lipid …, 2019 - ASBMB
Transintestinal cholesterol excretion (TICE) is a major route for eliminating cholesterol from
the body and a potential therapeutic target for hypercholesterolemia. The underlying
mechanism, however, is largely unclear, and its contribution to cholesterol disposal from the
body is obscured by the counteracting process of intestinal cholesterol reabsorption. To
determine the quantity of TICE independent from its reabsorption, we studied two models of
decreased intestinal cholesterol absorption. Cholesterol absorption was inhibited either by …
the body and a potential therapeutic target for hypercholesterolemia. The underlying
mechanism, however, is largely unclear, and its contribution to cholesterol disposal from the
body is obscured by the counteracting process of intestinal cholesterol reabsorption. To
determine the quantity of TICE independent from its reabsorption, we studied two models of
decreased intestinal cholesterol absorption. Cholesterol absorption was inhibited either by …