[HTML][HTML] Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis
Parathyroid hormone (PTH) stimulates bone formation when injected daily but causes
severe bone loss with continuous infusion. The mechanism of its paradoxical effects is still
elusive. In this study, we compared changes in the gene expression profile in bone induced
by intermittent or continuous treatment with three different PTH peptides, PTH-(1-34),-(1-31),
and-(3-34), in Sprague-Dawley female rats. PTH-(1-34) regulated numerous genes (∼
1,000), but differentially, in both regimes. PTH-(1-31) regulated a similar number of genes in …
severe bone loss with continuous infusion. The mechanism of its paradoxical effects is still
elusive. In this study, we compared changes in the gene expression profile in bone induced
by intermittent or continuous treatment with three different PTH peptides, PTH-(1-34),-(1-31),
and-(3-34), in Sprague-Dawley female rats. PTH-(1-34) regulated numerous genes (∼
1,000), but differentially, in both regimes. PTH-(1-31) regulated a similar number of genes in …