The amount of albumin filtered through the glomeruli and reabsorbed at the proximal tubules
in normal and in diabetic kidneys is debated. The megalin/cubilin complex mediates protein
reabsorption, but genetic knockout of megalin is perinatally lethal. To overcome current
technical problems, we generated a drug-inducible megalin–knockout mouse line, megalin
(lox/lox); Ndrg1-CreER T2 (iMegKO), in which megalin expression can be shut off at any
time by administration of tamoxifen (Tam). Tam administration in adult iMegKO mice …