[HTML][HTML] Ferret lung transplant: an orthotopic model of obliterative bronchiolitis
H Sui, AK Olivier, JA Klesney-Tait, L Brooks… - American journal of …, 2013 - Elsevier
Obliterative bronchiolitis (OB) is the primary cause of late morbidity and mortality following
lung transplantation. Current animal models do not reliably develop OB pathology. Given the
similarities between ferret and human lung biology, we hypothesized an orthotopic ferret
lung allograft would develop OB. Orthotopic left lower lobe transplants were successfully
performed in 22 outbred domestic ferrets in the absence of immunosuppression (IS; n= 5)
and presence of varying IS protocols (n= 17). CT scans were performed to evaluate the …
lung transplantation. Current animal models do not reliably develop OB pathology. Given the
similarities between ferret and human lung biology, we hypothesized an orthotopic ferret
lung allograft would develop OB. Orthotopic left lower lobe transplants were successfully
performed in 22 outbred domestic ferrets in the absence of immunosuppression (IS; n= 5)
and presence of varying IS protocols (n= 17). CT scans were performed to evaluate the …