Development of a vaccine against mental retardation caused by cytomegalovirus infection in utero
SD Elek, H Stern - The Lancet, 1974 - Elsevier
SD Elek, H Stern
The Lancet, 1974•ElsevierCytomegalovirus infection in utero is an important cause of mental retardation. A live tissue-
culture-adapted strain of the virus was tested in volunteers. The subcutaneous route of
inoculation was successful in stimulating neutralising and complement-fixing antibody
production without important side-effects. It is suggested that the use of such a vaccine in
adolescent girls would reduce the incidence of primary cytomegalovirus infection in
pregnancy and thus eliminate fetal brain damage due to this cause.
culture-adapted strain of the virus was tested in volunteers. The subcutaneous route of
inoculation was successful in stimulating neutralising and complement-fixing antibody
production without important side-effects. It is suggested that the use of such a vaccine in
adolescent girls would reduce the incidence of primary cytomegalovirus infection in
pregnancy and thus eliminate fetal brain damage due to this cause.
Abstract
Cytomegalovirus infection in utero is an important cause of mental retardation. A live tissue-culture-adapted strain of the virus was tested in volunteers. The subcutaneous route of inoculation was successful in stimulating neutralising and complement-fixing antibody production without important side-effects. It is suggested that the use of such a vaccine in adolescent girls would reduce the incidence of primary cytomegalovirus infection in pregnancy and thus eliminate fetal brain damage due to this cause.
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