Identification of a novel mutation and a genetic polymorphism of EVER1 gene in two families with epidermodysplasia verruciformis
YG Zuo, D Ma, Y Zhang, J Qiao, B Wang - Journal of dermatological …, 2006 - Elsevier
BACKGROUND: Epidermodysplasia verruciformis (EV) is a rare autosomal recessive
disease. The main clinical features include three kinds of lesions, high risk of skin cancer,
and abnormal susceptibility to HPV 5 and 8. Recent studies have shown that mutations in
EVER1 and EVER2 genes are responsible for the condition. OBJECTIVE: In the present
study, we investigated the molecular basis of EV in two families with EV. METHODS: PCR
and direct sequencing of the EVER1 and EVER2 genes were used to identify and confirm …
disease. The main clinical features include three kinds of lesions, high risk of skin cancer,
and abnormal susceptibility to HPV 5 and 8. Recent studies have shown that mutations in
EVER1 and EVER2 genes are responsible for the condition. OBJECTIVE: In the present
study, we investigated the molecular basis of EV in two families with EV. METHODS: PCR
and direct sequencing of the EVER1 and EVER2 genes were used to identify and confirm …