Leukocyte trafficking in primary immunodeficiencies

LD Notarangelo, R Badolato - Journal of Leucocyte Biology, 2009 - academic.oup.com
Journal of Leucocyte Biology, 2009academic.oup.com
Leukocyte recirculation through central and peripheral lymphoid organs and peripheral
tissues is essential to maintain immune homeostasis. Some of the genetically determined,
primary immunodeficiencies compromise leukocyte trafficking. Here, we review the
mechanisms and consequences of impaired leukocyte trafficking in leukocyte adhesion-
deficiency syndromes, Warts-Hypo-γ-globulinemia-Infections-Myelokathexis syndrome and
Wiskott-Aldrich syndrome.
Abstract
Leukocyte recirculation through central and peripheral lymphoid organs and peripheral tissues is essential to maintain immune homeostasis. Some of the genetically determined, primary immunodeficiencies compromise leukocyte trafficking. Here, we review the mechanisms and consequences of impaired leukocyte trafficking in leukocyte adhesion-deficiency syndromes, Warts-Hypo-γ-globulinemia-Infections-Myelokathexis syndrome and Wiskott-Aldrich syndrome.
Oxford University Press