[HTML][HTML] KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals
CL Hochstetler, Y Feng, M Sacma, AK Davis… - Experimental …, 2019 - Elsevier
Highlights•Endothelial KRas G12D expression affects normal hematopoiesis with a myeloid
bias.•Endothelial KRas G12D causes reduced HSC function in a competitive transplant
setting.•KRas G12D in endothelial cells elicits an inflammatory signal in the bone marrow
niche.The bone marrow (BM) niche is an important milieu where hematopoietic stem and
progenitor cells (HSPCs) are maintained. Previous studies have indicated that genetic
mutations in various components of the niche can affect hematopoiesis and promote …
bias.•Endothelial KRas G12D causes reduced HSC function in a competitive transplant
setting.•KRas G12D in endothelial cells elicits an inflammatory signal in the bone marrow
niche.The bone marrow (BM) niche is an important milieu where hematopoietic stem and
progenitor cells (HSPCs) are maintained. Previous studies have indicated that genetic
mutations in various components of the niche can affect hematopoiesis and promote …
