Alterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetes
SW Lee, KE Song, DS Shin, SM Ahn, ES Ha… - Diabetes research and …, 2005 - Elsevier
SW Lee, KE Song, DS Shin, SM Ahn, ES Ha, DJ Kim, MS Nam, KW Lee
Diabetes research and clinical practice, 2005•ElsevierBACKGROUND AND AIM:: In vivo and in vitro experimental findings indicate that the
hyperglycemic diabetic milieu can induce altered expression of the matrix metalloproteinase
(MMP) genes and contribute to imbalances in vascular matrix homeostasis. We examined
the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover.
METHODS:: We measured the plasma concentrations of MMP-2, MMP-9, and tissue inhibitor
of metalloproteinase 1 (TIMP-1) in 80 type-2 diabetic subjects without uremia and in 80 age …
hyperglycemic diabetic milieu can induce altered expression of the matrix metalloproteinase
(MMP) genes and contribute to imbalances in vascular matrix homeostasis. We examined
the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover.
METHODS:: We measured the plasma concentrations of MMP-2, MMP-9, and tissue inhibitor
of metalloproteinase 1 (TIMP-1) in 80 type-2 diabetic subjects without uremia and in 80 age …
BACKGROUND AND AIM
In vivo and in vitro experimental findings indicate that the hyperglycemic diabetic milieu can induce altered expression of the matrix metalloproteinase (MMP) genes and contribute to imbalances in vascular matrix homeostasis. We examined the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover.
METHODS
We measured the plasma concentrations of MMP-2, MMP-9, and tissue inhibitor of metalloproteinase 1 (TIMP-1) in 80 type-2 diabetic subjects without uremia and in 80 age-matched controls. In addition, we determined the plasma levels of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and high sensitive(hs) C-reactive protein (CRP) in both groups.
RESULTS
Plasma MMP-2, TIMP-1, and hs-CRP concentrations were significantly elevated in diabetic patients as compared to the control subjects (p<0.05). Plasma levels of MMP-2, MMP-9, TIMP-1, VCAM-1, ICAM-1, and hs-CRP were found not to be significantly associated with age, duration of diabetes, blood pressure, or serum lipid concentrations.
CONCLUSIONS
Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients.
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