Expression of gelatinases (MMP-2, MMP-9) and gelatinase activator (MMP-14) in actinic keratosis and in in situ and invasive squamous cell carcinoma
M Hernández-Pérez, M El-hajahmad… - The American Journal …, 2012 - journals.lww.com
Given the established role of matrix metalloproteinases (MMPs) in physiological processes
in the skin, we investigated the expression of MMP-2, MMP-9, and MMP-14 to evaluate their
role in the grading and development of atypical epithelial lesions. Immunohistochemistry
was performed using antibodies against these MMPs in actinic keratosis (AK; n= 24),
squamous cell carcinoma (SCC) in situ (SCCIS; n= 27), SCC well differentiated (SCCWD; n=
28), and SCC moderately to poorly differentiated (SCCMPD; n= 20). Tumoral and stromal …
in the skin, we investigated the expression of MMP-2, MMP-9, and MMP-14 to evaluate their
role in the grading and development of atypical epithelial lesions. Immunohistochemistry
was performed using antibodies against these MMPs in actinic keratosis (AK; n= 24),
squamous cell carcinoma (SCC) in situ (SCCIS; n= 27), SCC well differentiated (SCCWD; n=
28), and SCC moderately to poorly differentiated (SCCMPD; n= 20). Tumoral and stromal …