Vascular endothelial growth factor-A165b is protective and restores endothelial glycocalyx in diabetic nephropathy

S Oltean, Y Qiu, JK Ferguson, M Stevens… - Journal of the …, 2015 - journals.lww.com
Diabetic nephropathy is the leading cause of ESRD in high-income countries and a growing
problem across the world. Vascular endothelial growth factor-A (VEGF-A) is thought to be a
critical mediator of vascular dysfunction in diabetic nephropathy, yet VEGF-A knockout and
overexpression of angiogenic VEGF-A isoforms each worsen diabetic nephropathy. We
examined the vasculoprotective effects of the VEGF-A isoform VEGF-A 165 b in diabetic
nephropathy. Renal expression of VEGF-A 165 b mRNA was upregulated in diabetic …