Atorvastatin reduces NF-κB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells
M Ortego, C Bustos, MA Hernández-Presa, J Tuñón… - Atherosclerosis, 1999 - Elsevier
Cardiovascular mortality, mainly due to the rupture of unstable atherosclerotic plaques, is
reduced by 3-hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors.
Inflammatory cells, attracted to the vascular lesion by chemokines, have been implicated in
the process of the plaque rupture. In cultured vascular smooth muscle cells (VSMC) and
U937 mononuclear cells we have studied the effect of Atorvastatin (Atv) on nuclear factor κB
(NF-κB) activity, an inducer of the mRNA expression of chemokines such as interferon …
reduced by 3-hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors.
Inflammatory cells, attracted to the vascular lesion by chemokines, have been implicated in
the process of the plaque rupture. In cultured vascular smooth muscle cells (VSMC) and
U937 mononuclear cells we have studied the effect of Atorvastatin (Atv) on nuclear factor κB
(NF-κB) activity, an inducer of the mRNA expression of chemokines such as interferon …